Dual‐Light‐Triggered In Situ Structure and Function Regulation of Injectable Hydrogels for High‐Efficient Anti‐Infective Wound Therapy

• DOI: 10.1002/adhm.202101722
• Publication Date: 2021-09-27T16:51:34Z
• Authors: Yu Zhang; Haixia Wu; Peipei Li; Wenxin Liu; Yanling Zhang; Alideertu Dong
• Keywords: 0301 basic medicine; 03 medical and health sciences; Hydrogels; Hyaluronic Acid

Abstract Most injectable hydrogels used in biomedical engineering have unsatisfactory and untunable mechanical properties, making it difficult to match them with the strengths of different tissues organs, which can cause a series adverse consequences such as immune rejection soft tissue contusion. In this contribution, dopamine‐modified hyaluronic acid (HA‐DA) is developed backbone for an hydrogel using catechol–Fe 3+ coordination crosslinking strategy. Due dynamic physical crosslinking, be easily injected through single syringe. Into hydrogel, black phosphorous nanosheets loaded Zr‐based porphyrinic metal−organic framework (PCN@BP) are introduced that could generate reactive oxygen species (ROS) under 660 nm laser irradiation, promotes oxidative coupling dopamine presence ROS, introducing situ chemical into hydrogel. A physical/chemical double‐crosslinked obtained, effectively improving hydrogel's tuned by adjusting irradiation time modulus biological tissues. Combining excellent photothermal properties photodynamic performance PCN@BP yields effective sterilization mild conditions (below 50 °C, low ROS production). The results show multifunctional wound dressing.