Synthetic and Biodegradable Molybdenum(IV) Diselenide Triggers the Cascade Photo‐ and Immunotherapy of Tumor

• DOI: 10.1002/adhm.202200524
• Publication Date: 2022-05-25T08:44:35Z
• Authors: Jiulong Zhao; Yao Zhang; Jing Zhang; Hang Wu; Jinfeng Li; Yizhou Zhao; Liying Zhang; Duowu Zou; Zhaoshen Li; Shige Wang
• Keywords: Molybdenum; Photosensitizing Agents; Porphyrins; CD8-Positive T-Lymphocytes; Catalase; 01 natural sciences; 0104 chemical sciences; 3. Good health; Photochemotherapy; Cell Line, Tumor; Neoplasms; Tumor Microenvironment; Humans; Nanoparticles; Immunotherapy

AbstractIn this study, a polyvinylpyrrolidone (PVP)‐decorated MoSe2 (MoSe2‐PVP) nanoparticle with excellent photothermal transforming ability and chlorin E6 (Ce6) loading capacity is designed for combined tumor photothermal therapy (PTT), tumor photodynamic therapy (PDT), and immunotherapy. The light‐to‐heat conversion efficiency under irradiation with an 808 nm near‐infrared laser is as high as 59.28%. The MoSe2‐PVP NPs could function as an artificial catalase and catalyze the decomposition of H2O2. Their catalytic activity and thermal durability are higher than the native catalase, which relieve the tumor hypoxia status and sensitize the tumor PDT. The data show that the synthetic MoSe2‐PVP is biodegradable, owing to the oxidation of the Mo4+ to Mo6+. Moreover, its degradation products could increase the proportion of mature dendritic cells and CD8+ thymus (T) cells and promote the infiltration of active CD8+ T cells in tumors. The immune checkpoint inhibitor, programmed cell death protein 1 monoclonal antibody is combined with MoSe2‐PVP and it is found that its degradation product could efficiently change the immune microenvironment of the tumor.