Nature‐Skin‐Derived e‐Skin as Versatile “Wound Therapy‐Health Monitoring” Bioelectronic Skin‐Scaffolds: Skin to Bio‐e‐Skin

• DOI: 10.1002/adhm.202202971
• Publication Date: 2023-03-22T13:30:15Z
• Authors: Xinhua Liu; Boqiang Cui; Xuechuan Wang; Manhui Zheng; Zhongxue Bai; Ouyang Yue; Yifan Fei; Huie Jiang
• Keywords: Artificial skin; Human skin

Abstract Electronic skins (e‐skins) have the potential to turn into breakthroughs in biomedical applications. Herein, a novel acellular dermal matrix (ADM)‐based bioelectronic skin (e‐ADM) is used fabricate versatile “wound therapy‐health monitoring” tissue‐nanoengineered scaffolds via facile “one‐pot” bio‐compositing strategy incorporate conductive carbon nanotubes and self‐assembled micro‐copper oxide microspheres with cicada‐wing‐like rough surface nanocone microstructure. The e‐ADM exhibits robust tensile strength (22 MPa), flexibility, biodegradability, electroactivity, antibacterial properties. Interestingly, pH‐responsive ability for intelligent command between sterilization wound repair . Additionally, enables accurate real‐time monitoring of human activities, providing flexible e‐skin sensor record injury motions. In vitro vivo experiments show that electrical stimulation, could prominently facilitate cell growth proliferation further promote full‐thickness healing, comprehensive therapeutic smart sensing tissue repair, guiding development high‐performance skin‐scaffolds.