Integrated Cascade Nanozyme Remodels Chondrocyte Inflammatory Microenvironment in Temporomandibular Joint Osteoarthritis via Inhibiting ROS‐NF‐κB and MAPK Pathways

• DOI: 10.1002/adhm.202203195
• Publication Date: 2023-02-04T10:05:09Z
• Authors: Zhongyin Zhang; Lichan Yuan; Yufeng Liu; Ruobing Wang; Yihong Zhang; Yan Yang; Hui Wei; Junqing Ma
• Keywords: Chondrocytes; Temporomandibular Joint; Osteoarthritis; NF-kappa B; Animals; 02 engineering and technology; Reactive Oxygen Species; 0210 nano-technology; 3. Good health; Rats

Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative disease with no complete cure at present. Notably, the inflammatory microenvironment in TMJ OA modulated by oxidative stress, which impacts cartilage metabolism, chondrocyte apoptosis, cytokine release, and extracellular matrix (ECM) synthesis. Thus, it reasoned that reducing excess reactive oxygen species (ROS) may be an effective therapeutic strategy for OA. Recently, cascade nanozymes, including Pt@PCN222-Mn, have been exploited to treat ROS-associated diseases. Nevertheless, nanozymes are not employed therapy. To fill this gap, explored whether Pt@PCN222-Mn nanozyme could applied treatment of The vitro results demonstrate can inhibit production factors, degradation ECM, apoptosis chondrocytes inhibiting ROS-nuclear factor kappa-B (NF-κB_ mitogen-activated protein kinase signaling pathways. vivo further delay progression rat unilateral anterior crossbite model. It believed insightful perspectives on application will provided here.