Zinc‐Based Tannin‐Modified Composite Microparticulate Scaffolds with Balanced Antimicrobial Activity and Osteogenesis for Infected Bone Defect Repair

• DOI: 10.1002/adhm.202300303
• Publication Date: 2023-03-25T19:38:27Z
• Authors: Yitao Zhao; Jintao Li; Lingli Liu; Yue Wang; Yan Ju; Chun Zeng; Zhihui Lu; Denghui Xie; Jinshan Guo
• Keywords: Tannic acid

Treatment of infected bone defects is a major clinical challenge; bioactive materials combining sufficient antimicrobial activity and favorable osteogenic ability are urgently needed. In this study, through facile one-pot hydrothermal reaction zinc acetate in the presence tannic acid (TA), with or without silver nitrate (AgNO3 ), used to synthesize TA nanoparticles (Ag NPs) bulk-modified oxide (ZnO) (ZnO-TA ZnO-TA-Ag), which further composited zein fabricate porous microparticulate scaffolds for defect repair. Bulk modification significantly improves release rate antibacterial metal ions (Zn2+ >100 times that ZnO). Fast long-lasting (>35 d) Zn2+ Ag+ guaranteed capability excellent properties promoting differentiation marrow mesenchymal stem cells endogenous citric production mineralization providing considerable immunomodulatory M2 polarization macrophages. At same time, synchronously-released could scavenge reactive oxygen species (ROS) ROS produced by ions, effectively balancing osteogenesis sufficiently control infection while protecting surrounding tissue from damage, thus