Sm/Co‐Doped Silica‐Based Nanozymes Reprogram Tumor Microenvironment for ATP‐Inhibited Tumor Therapy

• DOI: 10.1002/adhm.202300652
• Publication Date: 2023-06-12T12:21:21Z
• Authors: Siyi Li; He Ding; Jinghu Chang; Shikai Liu; Shuming Dong; Mikhail V. Zyuzin; Alexander S. Timin; Lili Feng; Fei He; Shili Gai; Piaoping Yang
• Keywords: Reprogramming

Current applications of multifunctional nanozymes for reprogramming the redox homeostasis tumor microenvironment (TME) have been severely confronted with low catalytic activity and ambiguity active sites nanozymes, as well stress resistance from rigorous physical environment cells. Herein, Sm/Co-doped mesoporous silica 3PO-loaded (denoted mSC-3PO) are rationally constructed simultaneously inhibiting energy production by adenosine triphosphate (ATP) inhibitor 3PO TME multiactivities photothermal effect assist, i.e., enhanced peroxidase-like, catalase-like activity, glutathione peroxidase-like activities, facilitating reactive oxygen species (ROS) generation, promoting content, restraining over-expressed glutathione. Through optimal regulation nanometric size doping ratio, fabricated superparamagnetic mSC-3PO enables excellent exposure avoids agglomeration owing to large specific surface structure, thus providing adequate enough spatial distribution. The Sm/Co centers both participate in simulated biological enzyme reactions carry out double-center process (Sm3+ Co3+ /Co2+ ). Significantly, glycolysis, can reduce ATP flow cutting down transform, thereby angiogenesis assisting ROS promote early withering In addition, considerable near-infrared (NIR) light absorption adapt NIR excitable treatment therapy photoexcitation-promoted enzymatic reactions. Taken together, this work presents a typical therapeutic paradigm that reprograms promotes cell apoptosis assistance.