Platelet‐Membrane‐Coated Polydopamine Nanoparticles for Neuroprotection by Reducing Oxidative Stress and Repairing Damaged Vessels in Intracerebral Hemorrhage

• DOI: 10.1002/adhm.202300797
• Publication Date: 2023-06-13T17:05:31Z
• Authors: Canxin Xu; Yuanbo Pan; Hongchi Zhang; Yuhao Sun; Yi Cao; Pengfei Qi; Mingli Li; Ozioma Udochukwu ...; Lulu He; Chen Xiao; Bomin Sun; Liuguan Bian; Juan Li; Aiguo Wu
• Keywords: Oxidative Stress; Disease Models, Animal; Animals; Reactive Oxygen Species; Neuroprotection; Cerebral Hemorrhage

Intracerebral hemorrhage (ICH) has a high morbidity and mortality rate. Excessive reactive oxygen species (ROS) caused by primary second brain injury can induce neuron death inhibit neurological functional recovery after ICH. Therefore, exploring an effective way to noninvasively target sites scavenge ROS is urgently needed. Inspired the biological function of platelets vessel repair blood vessels, platelet-membrane-modified polydopamine (Menp@PLT) nanoparticles are developed with targeting Results demonstrate that Menp@PLT effectively achieve location intracranial hematoma. Furthermore, excellent anti-ROS properties improve neuroinflammation microenvironment In addition, may play role in decreasing volume repairing vessels. Combining platelet membrane for provide promising strategy efficiently treating