Integrated Piezoelectric/Conductive Composite Cryogel Creates Electroactive Microenvironment for Enhanced Bone Regeneration

• DOI: 10.1002/adhm.202300927
• Publication Date: 2023-06-01T20:39:22Z
• Authors: Tianyi Zheng; Yanyun Pang; Daixing Zhang; Yue Wang; Xu Zhang; Huijie Leng; Yingjie Yu; Xiaoping Yang; Qing Cai
• Keywords: Gelatin

Natural bone tissue possesses inherent electrophysiological characteristics, displaying conductivity and piezoelectricity simultaneously; hence, the reconstruction of local electrical microenvironment at defect site provides an effective strategy to enhance osteogenesis. Herein, a composite cryogel-type scaffold (referred as Gel-PD-CMBT) is developed for regeneration, utilizing gelatin (Gel) in combination with conductive poly(ethylene dioxythiophene)/polystyrene sulfonate matrix Ca/Mn co-doped barium titanate (CMBT) nanofibers piezoelectric filler. The incorporation these components results formation integrated piezoelectric/conductive network within scaffold, facilitating charge migration yielding 0.59 S cm-1 . This creates promising electroactive microenvironment, which capable up-regulating biological responses. Furthermore, interconnected porous structure Gel-PD-CMBT not only mechanical stability but also offered ample space cellular ingrowth. demonstrates greater capacity promote osteogenic differentiation vitro neo-bone vivo. In summary, its conductivity, effectively restores offering ideal platform regeneration tissue.