Modular Titratable Polypills for Personalized Medicine and Simplification of Complex Medication Regimens

• DOI: 10.1002/adhm.202301101
• Publication Date: 2023-08-01T11:39:36Z
• Authors: Christina Karavasili; Sahab Babaee; Shruti Kutty; Jacqueline N. Chu; Seokkee Min; Nina Fitzgerald; Joshua Morimoto; Nicoletta Inverardi; Giovanni Traverso
• Keywords: Fixed-dose combination; Polypill

Simplification of complex medication regimens in polypharmacy positively contributes to treatment adherence and cost-effective improved health outcomes. Even though fixed dose combination (FDC) drug products are the only currently available single poly-pill regimens, lack flexibility adjustment a limits their efficacy. To fill existing gap personalization simplification commonly encountered cardiovascular disease, tuberculosis, tapering corticosteroid therapy, modular titratable polypill approach that simultaneously addresses both aspects is proposed. The consists units contain different drugs at incremental or decremental doses be assembled required for each through stacking interlocking process. variable (VD) tablets subjected quality control tests found comply pharmacopeia's acceptance criteria requirements specified respective monographs. A cost-effectiveness analysis conducted supporting VD strategy as compared FDC more effective less expensive than standard care. stands enable pill burden reduction, ease administration, enhancement adherence, potential cost-saving benefits.