X‐Ray Nanothermometry of Nanoparticles in Tumor‐Mimicking Tissues under Photothermia

• DOI: 10.1002/adhm.202301863
• Publication Date: 2023-07-18T23:59:42Z
• Authors: Rosalía López‐Méndez; Javier Reguera; Alexandre Fromain; Esraa Samy Abu Serea; Eva Céspedes; Francisco Jose Teran; Fangyuan Zheng; Ana Parente; Miguel Ángel García; Emiliano Fonda; Julio Camarero; Claire Wilhelm; Álvaro Muñoz‐Noval; Ana Espinosa
• Keywords: Photoexcitation

Temperature plays a critical role in regulating body mechanisms and indicating inflammatory processes. Local temperature increments above 42 °C are shown to kill cancer cells tumorous tissue, leading the development of nanoparticle-mediated thermo-therapeutic strategies for fighting oncological diseases. Remarkably, these therapeutic effects can occur without macroscopic rise, suggesting localized nanoparticle heating, minimizing side on healthy tissues. Nanothermometry has received considerable attention as means developing nanothermosensing approaches monitor at core atoms inside cells. In this study, label-free, direct, universal nanoscale thermometry is proposed thermal processes nanoparticles under photoexcitation tumor environment. Gold-iron oxide nanohybrids utilized multifunctional photothermal agents internalized 3D model glioblastoma that mimics vivo scenario. The local near-infrared photo-excitation monitored by X-ray absorption spectroscopy (XAS) Au L