Nanofiber Composite Microchannel‐Containing Injectable Hydrogels for Cartilage Tissue Regeneration

• DOI: 10.1002/adhm.202302293
• Publication Date: 2023-09-10T09:28:23Z
• Authors: Jia Liu; Chen Tang; Jian Huang; Jinhong Gu; Jingbo Yin; Guohua Xu; Shifeng Yan
• Keywords: Chondrogenesis; Gelatin; Electrospinning; Microchannel

Abstract Articular cartilage tissue is incapable of self‐repair and therapies for defects are still lacking. Injectable hydrogels have drawn much attention in the field regeneration. Herein, novel design nanofiber composite microchannel‐containing inspired by tunnel‐piled structure subway tunnels proposed. Based on aldehydized polyethylene glycol/carboxymethyl chitosan (APA/CMCS) hydrogels, thermosensitive gelatin microrods (GMs) used as a pore‐forming agent, coaxial electrospinning polylactic acid/gelatin fibers (PGFs) loaded with kartogenin (KGN) reinforcing agent drug delivery system to construct injectable (APA/CMCS/KGN@PGF/GM hydrogels). The situ formation, micromorphology porosity, swelling degradation, mechanical properties, self‐healing behavior, well release investigated. hydrogel exhibits good ability, introduction PGF nanofibers can significantly improve properties. realize sustained KGN match process repair. microchannel effectively promotes bone marrow mesenchymal stem cell (BMSC) proliferation ingrowth within hydrogels. In vitro animal experiments indicate that APA/CMCS/KGN@PGF/GM enhance chondrogenesis BMSCs promote neocartilage formation rabbit defect model.