Surface Modification of Nerve Guide Conduits with ECM Coatings and Investigating Their Impact on Schwann Cell Response

• DOI: 10.1002/adhm.202304103
• Publication Date: 2024-02-24T06:19:35Z
• Authors: Luis Pinzon‐Herrera; John Magness; Hector Apodaca‐Reyes; Jesus Sanchez; Jorge Almodovar
• Keywords: Viability assay; Schwann cell

In this study, layer-by-layer coatings composed of heparin and collagen are proposed as an extracellular mimetic environment on nerve guide conduits (NGC) to modulate the behavior Schwann cells (hSCs). The authors evaluated stability, degradation over time, bioactivity six bilayers heparin/collagen coatings, denoted (HEP/COL)