Herbal Products‐Powered Thermosensitive Hydrogel with Phototherapy and Microenvironment Reconstruction for Accelerating Multidrug‐Resistant Bacteria‐Infected Wound Healing

• DOI: 10.1002/adhm.202400049
• Publication Date: 2024-02-28T17:53:35Z
• Authors: Gang Zhao; Guanghua Lu; Huizhen Fan; Li Wei; Qiang Yu; Ming Li; Hanqing Li; Nuo Yu; Shen Wang; Min Lu
• Keywords: Thymoquinone

Abstract Wound healing and infection remain significant challenges due to the ineffectiveness against multidrug‐resistant (MDR) bacteria complex oxidative wound microenvironments. To address these issues, thymoquinone‐reinforced injectable thermosensitive TQ@PEG‐PAF‐Cur hydrogels with dual functions of microenvironment reshaping photodynamic therapy are developed. The hydrogel comprises natural compound thymoquinone (TQ) poly (ethylene glycol)‐block‐poly (alanine‐co‐phenyl alanine) copolymers (PEG‐PAF) conjugated photosensitizer curcumin (Cur). incorporation TQ Cur reduces sol‐to‐gel transition temperature 30°C, compared PEG‐PAF (37°C), formation strong hydrogen bonding, matching temperature. Under blue light excitation, generates amounts reactive oxygen species such as H 2 O , 1O ·OH, exhibiting rapid efficient bactericidal capacities methicillin‐resistant Staphylococcus aureus broad spectrum β‐lactamases Escherichia coli via (PDT). Additionally, effectively inhibits expressions proinflammatory cytokines in skin tissue‐forming cells. As a result, composite can rapidly transform into gel cover wound, reshape microenvironment, accelerate vivo. This collaborative antibacterial strategy provides valuable insights guide development multifunctional materials for healing.