Electroactive Asymmetric Dressing for Spatiotemporal Deep Burn Scarless Healing and Management

• DOI: 10.1002/adhm.202404266
• Publication Date: 2025-01-11T07:05:44Z
• Authors: Hanbai Wu; Xiong Zhou; Chuanwei Zhi; Cong Wang; Yuhan Chen; Yifan Si; Jieqiong Yang; Qi Zhang; Raymond H. W. Lam; Tingwu Qin; Guibing Fu; Zhu Xiong; Jinlian Hu

Burn care and treatment differ markedly from other types of wounds, as they are significantly more prone to infections struggle maintain fluid balance post-burn. Moreover, the limited self-healing abilities exacerbate likelihood scar formation, further complicating recovery process. To tackle these issues, an asymmetric wound dressing comprising a quercetin-loaded poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P34HB@Qu) hydrophilic layer zinc oxide nanoparticle-loaded, thermally treated polyvinylidene fluoride (HPVDF@ZnO) hydrophobic is designed. This provided antibacterial property exudate management in early stages burn treatment, preventing infection maintaining moisture at site. As healing progresses, electroactive properties HPVDF@ZnO quercetin P34HB@Qu synergistically regulate cell migration differentiation, accelerating facilitating scar-free regeneration. Furthermore, assisted regeneration skin appendages. study underscores full-cycle strategy versatile dressings for spatiotemporal injury scarless healing.