Polymer‐Conjugated SOD‐Pt⁰ Micelles Enhance ROS Cascade Scavenging to Alleviate Ischemia‐Reperfusion Injury During Kidney Transplantation

• DOI: 10.1002/adhm.202500696
• Publication Date: 2025-05-21T05:51:02Z
• Authors: Shengzhou Li; Fei Duan; Zhiwen Qiu; Zhuofan Nan; Xiangqian Cao; Chenkai Yang; Wei Li; Bing Shen

Abstract Ischemia‐reperfusion injury (IRI) during kidney transplantation is linked to oxidative stress induced by excessive reactive oxygen species (ROS), which causes the of transplanted kidney, leading further intensified organ shortages. Protein‐based antioxidants have been developed for ROS scavenging via cascade biocatalyst. The in situ growth metal nanozymes on proteins effectively decreases steric hindrance between active sites, improving efficiency biocatalysts. However, poor stability protein process preparation and intracellular delivery leads low therapeutic effects. In this study, three different functional polymers are conjugated SOD formation micelles. Surprisingly, it found that ultra‐acid sensitive polymer efficiently preserves enzymatic activity SOD, due great endo/lysosomal escape capacity. Subsequently, micelles (SOE) used as a template prepare SOE‐Pt 0 (SOEP) through Pt with vicinal sites. minimally impacts owing improved stability. system exhibits effective scavenging, significantly reducing damage inflammation caused IRI. research offers novel approach addressing IRI challenges provides promising strategy mitigate