Harnessing Aggregation‐Induced Emission and Multi‐FRET Strategies in a Single Conjugated Polymer Nanosystem for Enhanced Antibacterial Phototheranostics at Minimal Dosage

• DOI: 10.1002/adhm.202500794
• Publication Date: 2025-05-19T08:15:36Z
• Authors: Chunhong Zhu; Sameer Hussain; Ziyu Yue; Kaili Wang; Long Zhang; Mohammad Adil Afroz; Chunqiang Liu; Cibin Zhao; Xinyu Zhang; Ansar Abbas; Jingang An; Yi Hao; Ruixia Gao

Abstract Developing effective antibacterial photosensitizers with excellent fluorescence properties, enhanced reactive oxygen species (ROS) generation, and low dosage requirements is highly desirable but remains a major challenge. Herein, new aggregation‐induced emission (AIE)‐active conjugated polymer (FTDM) remarkable light‐harvesting properties designed synthesized by smartly engineering AIE multi‐FRET processes in its molecular structure. Thanks to donor‐π‐acceptor configuration, involvement of mechanisms, the notable effect, as‐fabricated water dispersible nanoparticles FTDM (FTDM NPs) demonstrate outstanding high ROS generation ability compared non‐AIE model (FDM) common photosensitizer Chlorin E6. Efficient bioimaging photodynamic activity are achieved using NPs under white light irradiation (20 mW cm −2 ) for 15 min, demonstrating over 99.99% efficacy against E. coli at remarkably 0.6 µg mL −1 . Furthermore, mechanically stable hydrogel matrix NPs@gel) use as wound dressing attained which demonstrated accelerated healing inhibiting eliminating bacteria through effect an infected mouse without causing any toxicity. Thus, intelligently antimicrobial nanosystems can be revolutionary minimizing toxicity combating menace drug resistance.