Geometric Adjustment of T Cell‐Sensitive Nanorobots for Enhanced Stability

• DOI: 10.1002/adhm.202500846
• Publication Date: 2025-05-27T12:17:00Z
• Authors: Yoojin Lee; Dahae Kim; Taihyun Kim; Chae‐Won Moon; Hyungseok Yong; Sung‐eun Heo; Bumgyu Choi; Yoogyeong Oh; Woojin Choi; Kyungtae Park; Sang‐Jun Ha; Jinkee Hong
• Keywords: Nanorobotics

Abstract Personalized dendritic cell (DC) based vaccines offer promising immunotherapeutic approaches for cancers and infectious diseases by leveraging living DCs to stimulate a patient's immune system through interactions with T cells. However, conventional DC‐based face significant challenges, including limited stability short storage lifespan of the To overcome these limitations, smart artificial nanorobots, termed nano‐bone marrow (BMDC)‐originated activators (nano‐BOTs) are developed incorporating 1‐dimensional (1D) nanoparticles enhance activation efficacy. The use 1D enables precise modulation geometric properties, resulting in significantly improved effector This innovative approach addresses inherent limitations traditional amplifies their ability activate advanced nanorobots exhibit exceptional therapeutic potential, representing transformative step toward personalized future biological therapeutics.