Mn2+ Dopant‐Controlled Synthesis of NaYF4:Yb/Er Upconversion Nanoparticles for in vivo Imaging and Drug Delivery

• DOI: 10.1002/adma.201104741
• Publication Date: 2012-01-27T08:52:13Z
• Authors: Gan Tian; Zhanjun Gu; Liangjun Zhou; Wenyan Yin; Xiaoxiao Liu; Liang Yan; Shan Jin; Wenlu Ren; Gengmei Xing; Shoujian Li; Yuliang Zhao
• Keywords: Drug Carriers; Manganese; Antibiotics, Antineoplastic; Luminescence; 01 natural sciences; 0104 chemical sciences; 3. Good health; Fluorides; Mice; Doxorubicin; Animals; Nanoparticles; Yttrium; Ytterbium; Erbium

Pure dark red emission (650-670 nm) of NaYF(4):Yb/Er upconversion nanoparticles (UCNPs) is achieved by manganese ions (Mn(2+)) doping. In addition, the Mn(2+)-doping can also control the crystalline phase and size of the resulting UCNPs simultaneously. Drug delivery studies suggest the promise of these UCNPs as drug carriers for intracellular drug delivery and eventually as a multifunctional nanoplatform for simultaneous diagnosis and therapy.