Weakly Charged Cationic Nanoparticles Induce DNA Bending and Strand Separation

• DOI: 10.1002/adma.201104891
• Publication Date: 2012-06-19T07:16:19Z
• Authors: Justin G. Railsback; Abhishek Singh; Ryan C. Pearce; Timothy E. McKnight; Ramón Collazo; Zlatko Sitar; Yaroslava G. Ying...; Anatoli V. Melechko
• Keywords: Cationic polymerization; Helix (gastropod)

Weakly charged cationic nanoparticles cause structural changes including local denaturing and compaction to DNA under mild conditions. The ligands bind the phosphate backbone of uncharged penetrate helix disrupt base pairing. Mobility shifts in electrophoresis, molecular dynamics, UV-vis spectrophotometry give clues details interactions. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by authors. Please note: publisher is responsible for content functionality any supporting information supplied Any queries (other than missing content) should be directed corresponding author article.