Theranostic Probe Based on Lanthanide‐Doped Nanoparticles for Simultaneous In Vivo Dual‐Modal Imaging and Photodynamic Therapy

• DOI: 10.1002/adma.201202433
• Publication Date: 2012-08-23T10:15:12Z
• Authors: Yong Il Park; Hyung Min Kim; Jeong Hyun Kim; Kyung Chul Moon; Byeongjun Yoo; Kang Taek Lee; Nohyun Lee; Yoonseok Choi; Wooram Park; Daishun Ling; Kun Na; Woo Kyung Moon; Seung Hong Choi; Hong Seok Park; Soo‐Young Yoon; Yung Doug Suh; Sung Ho Lee; Taeghwan Hyeon
• Keywords: Chlorin; Photon Upconversion

Dual-modal in vivo tumor imaging and photodynamic therapy using hexagonal NaYF4:Yb,Er/NaGdF4 core–shell upconverting nanoparticles combined with a photosensitizer, chlorin e6, is reported. Tumors can be clearly observed not only the upconversion luminescence image but also magnetic resonance image. In by systemic administration demonstrated under 980 nm irradiation. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, copy-edited or typeset. They made available submitted authors. Please note: The publisher responsible for content functionality any supporting information supplied Any queries (other than missing content) should directed corresponding author article.