Bacteria‐Responsive Multifunctional Nanogel for Targeted Antibiotic Delivery

• DOI: 10.1002/adma.201202847
• Publication Date: 2012-09-10T09:35:27Z
• Authors: Meng‐Hua Xiong; Ya‐Juan Li; Yan Bao; Xian‐Zhu Yang; Bing Hu; Jun Wang
• Keywords: Nanogel; Targeted drug delivery

Bacteria-Responsive Multifunctional Nanogel: We developed a bacteria-responsive multifunctional nanogel for targeted antibiotic delivery, in which bacterial enzymes are utilized to trigger release by degrading the polyphosphoester core. The mannosylated preferentially delivers drugs macrophages and leads drug accumulation at infection sites through macrophage transport. This provides targeting lesion site-activatable properties, enhances growth inhibition. Detailed facts of importance specialist readers published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted authors. Please note: publisher is responsible content functionality any supporting information supplied Any queries (other than missing content) should be directed corresponding author article.