Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability

• DOI: 10.1002/adma.201204346
• Publication Date: 2013-01-04T16:13:18Z
• Authors: Ahmed A. Eltoukhy; Delai Chen; Christopher A. Alabi; Robert Langer; Daniel G. Anderson
• Keywords: Cell Survival; Polymers; DNA; 02 engineering and technology; Transfection; Lipids; Polyethylene Glycols; Humans; Nanoparticles; 0210 nano-technology; Hydrophobic and Hydrophilic Interactions; HeLa Cells

Degradable, cationic poly(β-amino ester)s (PBAEs) with alkyl side chains are developed for non-viral gene delivery. Nanoparticles formed from these PBAE terpolymers exhibit significantly enhanced DNA transfection potency and resistance to aggregation. These hydrophobic terpolymers, but not PBAEs lacking chains, support interaction PEG-lipid conjugates, facilitating their functionalization shielding targeting moieties accelerating the in vivo translation of materials. As a service our authors readers, this journal provides supporting information supplied by authors. Such materials peer reviewed may be re-organized online delivery, copy-edited or typeset. Technical issues arising (other than missing files) should addressed Please note: The publisher is responsible content functionality any Any queries content) directed corresponding author article.