Single Continuous Wave Laser Induced Photodynamic/Plasmonic Photothermal Therapy Using Photosensitizer‐Functionalized Gold Nanostars

• DOI: 10.1002/adma.201204623
• Publication Date: 2013-02-13T07:36:40Z
• Authors: Shouju Wang; Peng Huang; Liming Nie; Ruijun Xing; Dingbin Liu; Zhe Wang; Jing Lin; Shouhui Chen; Gang Niu; Guangming Lu; Xiaoyuan Chen
• Keywords: Photosensitizing Agents; Lasers; Metal Nanoparticles; Breast Neoplasms; 02 engineering and technology; Photodynamic therapy; Photosensitizers; Mice; Cell Transformation, Neoplastic; Photochemotherapy; Cell Line, Tumor; Animals; Humans; Biocompatibility; Gold; 0210 nano-technology; Continuous wave lasers

Chlorin e6 conjugated gold nanostars (GNS-PEG-Ce6) are used to perform simultaneous photodynamic/plasmonic photothermal therapy (PDT/PPTT) upon single laser irradiation. The early-phase PDT effect is coordinated with the late-phase PPTT effect to obtain synergistic anticancer efficiency. The prepared GNS-PEG-Ce6 shows excellent water dispersibility, good biocompatibility, enhanced cellular uptake and remarkable anticancer efficiency upon irradiation in vivo.