Construction of Robust Enzyme Nanocapsules for Effective Organophosphate Decontamination, Detoxification, and Protection

• DOI: 10.1002/adma.201205138
• Publication Date: 2013-02-25T08:37:34Z
• Authors: Wei Wei; Juanjuan Du; Jie Li; Ming Yan; Qi Zhu; Xin Jin; Xinyuan Zhu; Zuming Hu; Yi Tang; Yunfeng Lu
• Keywords: Aryldialkylphosphatase; Cell Survival; Polymers; 3T3 Cells; 02 engineering and technology; Enzymes, Immobilized; Organophosphates; Paraoxon; Kinetics; Mice; Nanocapsules; Animals; Humans; Chemical Warfare Agents; Pesticides; 0210 nano-technology; HeLa Cells

Nanocapsules of organophosphorous hydrolase with enhanced enzyme activity and stability are prepared via in situ polymerization, providing a novel class of nanoparticles for the decontamination and detoxification of organophosphates such as chemical warfare agents and pesticides. Using the nanocapsules as building blocks, bioactive nanocomposites are also fabricated, enabling their use for organophosphate protection.