Lipid Nanoparticles: Peptide Targeted Lipid Nanoparticles for Anticancer Drug Delivery (Adv. Mater. 28/2012)

• DOI: 10.1002/adma.201290171
• Publication Date: 2012-07-19T06:47:21Z
• Authors: Timothy R. Pearce; Kamlesh Shroff; Efrosini Kokkoli
• Keywords: Internalization; Targeted drug delivery

Nanoparticles reach the tumor through “leaky” vasculature that allows transfer of large molecules out blood stream. Once in microenvironment targeting peptides on surface nanoparticles allow specific binding by tumor-cell receptors and subsequent cell internalization. On page 3803, E. Kokkoli co-workers review recent strategies used to create peptide-targeted lipid nano-particles improve cancer therapy.