Periosteum‐Mimetic Structures Made from Freestanding Microgrooved Nanosheets

adhesiveness 02 engineering and technology micropattern nanosheet Bone and Bones Polylactic Acid-Polyglycolic Acid Copolymer Biomimetic Materials Osteogenesis Periosteum Cell Adhesion Animals Humans Lactic Acid Cells, Cultured Tissue Scaffolds periosteum Water Mesenchymal Stem Cells bone repair Nanostructures Microscopy, Electron, Scanning 0210 nano-technology Chickens Porosity Polyglycolic Acid
DOI: 10.1002/adma.201305804 Publication Date: 2014-03-11T07:24:44Z
ABSTRACT
A "sticker-like" PLGA nanosheet with microgrooved patterns is developed through a facile combination of spin coating and micropatterning techniques. The resulting microgrooved PLGA nanosheets can be physically adhered on flat or porous surfaces with excellent stability in aqueous environments and can harness the spatial arrangements of cells, which make it a promising candidate for generating biomimic periosteum for bone regenerative applications.
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