Periosteum‐Mimetic Structures Made from Freestanding Microgrooved Nanosheets

• DOI: 10.1002/adma.201305804
• Publication Date: 2014-03-11T07:24:44Z
• Authors: Xuetao Shi; Toshinori Fujie; Akihiro Saito; Shinji Takeoka; Ying Hou; Yiwei Shu; Mingwei Chen; Hongkai Wu; Ali Khademhosseini
• Keywords: 0301 basic medicine; adhesiveness; 02 engineering and technology; micropattern; nanosheet; Bone and Bones; 03 medical and health sciences; Polylactic Acid-Polyglycolic Acid Copolymer; Biomimetic Materials; Osteogenesis; Periosteum; Cell Adhesion; Animals; Humans; Lactic Acid; Cells, Cultured; Tissue Scaffolds; periosteum; Water; Mesenchymal Stem Cells; bone repair; Nanostructures; 3. Good health; Microscopy, Electron, Scanning; 0210 nano-technology; Chickens; Porosity; Polyglycolic Acid

A "sticker-like" PLGA nanosheet with microgrooved patterns is developed through a facile combination of spin coating and micropatterning techniques. The resulting microgrooved PLGA nanosheets can be physically adhered on flat or porous surfaces with excellent stability in aqueous environments and can harness the spatial arrangements of cells, which make it a promising candidate for generating biomimic periosteum for bone regenerative applications.