Integrating Oxaliplatin with Highly Luminescent Carbon Dots: An Unprecedented Theranostic Agent for Personalized Medicine

• DOI: 10.1002/adma.201306192
• Publication Date: 2014-03-14T16:56:28Z
• Authors: Min Zheng; Shi Liu; Jing Li; Dan Qu; Haifeng Zhao; Xingang Guan; Xiuli Hu; Zhigang Xie; Xiabin Jing; Zaicheng Sun
• Keywords: Organoplatinum Compounds; Cell Survival; Carbon Compounds, Inorganic; Optical Imaging; Antineoplastic Agents; Hep G2 Cells; 02 engineering and technology; Fibroblasts; Fluorescence; Cell Line; 3. Good health; Oxaliplatin; Mice; Nanomedicine; Cell Line, Tumor; Quantum Dots; Animals; Humans; Drug Monitoring; Particle Size; Precision Medicine; 0210 nano-technology; HeLa Cells

A theranostic nanomedicine (CD-Oxa) is synthesized by means of the condensation reaction between the amino groups on the surface of fluorescent carbon dots (CDs) and the carboxyl group of the oxaliplatin derivative Oxa(IV)-COOH. CD-Oxa, which integrates the optical properties of CDs and the anticancer function of oxaliplatin, could be used for simultaneous drug delivery and fluorescent tracking.