Ultrasmall Au10−12(SG)10−12 Nanomolecules for High Tumor Specificity and Cancer Radiotherapy

• DOI: 10.1002/adma.201400866
• Publication Date: 2014-05-11T17:44:59Z
• Authors: Xiao‐Dong Zhang; Zhentao Luo; Jie Chen; Xiu Shen; Shasha Song; Yuanming Sun; Saijun Fan; Feiyue Fan; David Tai Leong; Jianping Xie
• Keywords: 0301 basic medicine; Radiation-Sensitizing Agents; Biological Transport, Active; Metal Nanoparticles; Mice, Nude; FOS: Physical sciences; Quantitative Biology - Tissues and Organs; Neoplasms, Experimental; Physics - Medical Physics; Glutathione; 01 natural sciences; 0104 chemical sciences; 3. Good health; Mice; 03 medical and health sciences; Biological Physics (physics.bio-ph); FOS: Biological sciences; Animals; Physics - Biological Physics; Gold; Medical Physics (physics.med-ph); Tissues and Organs (q-bio.TO)

21 pages, 11 figures<br/>Radiosensitizers can increase the local treatment efficacy under a relatively low and safe radiation dose, thereby facilitating tumor eradication and minimizing side effects. Here, we report a new class of radiosensitizers that contain several gold (Au) atoms embedded inside a peptide shell (e.g., Au10-12(SG)10-12) and can achieve ultrahigh tumor uptake (10.86 SUV at 24 h post injection) and targeting specificity, efficient renal clearance, and high radiotherapy enhancement.<br/>