Core–Shell Upconversion Nanoparticle@Metal–Organic Framework Nanoprobes for Luminescent/Magnetic Dual‐Mode Targeted Imaging

• DOI: 10.1002/adma.201501779
• Publication Date: 2015-06-05T16:29:30Z
• Authors: Yantao Li; Jinglong Tang; Liangcan He; Yong Liu; Yaling Liu; Chunying Chen; Zhiyong Tang
• Keywords: Luminescence; Cell Survival; Contrast Media; Mice, Nude; Biocompatible Materials; 01 natural sciences; Polyethylene Glycols; Engineering; Microscopy, Electron, Transmission; X-Ray Diffraction; Cell Line, Tumor; Animals; Humans; Materials engineering not elsewhere classified; Magnetite Nanoparticles; Mice, Inbred BALB C; Microscopy, Confocal; Spectrum Analysis; Water; Magnetic Resonance Imaging; 0104 chemical sciences; Physical sciences; Chemical sciences; Luminescent Measurements; Neoplasm Transplantation

Core-shell upconversion nanoparticle@metal-organic framework (UCNP@MOF) nanostructures are constructed by coating hexagonal NaYF4 :Yb,Er nanoparticle (NP) cores with amino-functionalized iron carboxylate MOF shells. These nanostructures combine the near-infrared optical property of the UCNP cores and the T2 -magnetic response (MR) imaging property of the MOF shells. After surface modification, the core-shell nanostructures are demonstrated as high-resolution nanoprobes for targeted luminescence/MR imaging both in vitro and in vivo.