Diketopyrrolopyrrole‐Based Semiconducting Polymer Nanoparticles for In Vivo Photoacoustic Imaging

• DOI: 10.1002/adma.201502285
• Publication Date: 2015-08-06T13:33:50Z
• Authors: Kanyi Pu; Jianguo Mei; Jesse V. Jokerst; Guosong Hong; Alexander L. Antaris; Niladri Chattopad...; Adam J. Shuhendler; Tadanori Kurosawa; Yan Zhou; Sanjiv S. Gambhir; Zhenan Bao; Jianghong Rao
• Keywords: Models, Molecular; semiconducting polymer nanoparticles; Polymers; Molecular Conformation; Bioengineering; 02 engineering and technology; Cell Transformation; Macromolecular and Materials Chemistry; Photoacoustic Techniques; Mice; Engineering; Models; Nanotechnology; Animals; Humans; Pyrroles; Nanoscience & Nanotechnology; Neoplastic; tumor imaging; Molecular; Materials Engineering; contrast agent; Ketones; Physical sciences; Cell Transformation, Neoplastic; Chemical sciences; Semiconductors; Hela Cells; Chemical Sciences; Physical Sciences; Nanoparticles; photoacoustic imaging; 0210 nano-technology; photothermal imaging; Biotechnology; HeLa Cells

Diketopyrrolopyrrole-based semiconducting polymer nanoparticles with high photostability and strong photoacoustic brightness are designed and synthesized, which results in 5.3-fold photoacoustic signal enhancement in tumor xenografts after systemic administration.