Tissue‐Integratable and Biocompatible Photogelation by the Imine Crosslinking Reaction

• DOI: 10.1002/adma.201505336
• Publication Date: 2016-02-03T19:21:40Z
• Authors: Yunlong Yang; Jieyuan Zhang; Zhenzhen Liu; Qiuning Lin; Xiaolin Liu; Chunyan Bao; Yang Wang; Linyong Zhu
• Keywords: Imine; Biocompatible material; Nitrobenzene

A novel photogelling mechanism by the phototriggered-imine-crosslinking (PIC) reaction is demonstrated. Hyaluronic acid grafted with o-nitrobenzene, a photogenerated aldehyde group, can quickly photo-crosslink amino-bearing polymers or proteins. Once in situ on wound occurs, PIC gelling process well integrate hydrogel surrounding tissue covalent bonding, thus making it powerful tool for engineering and regenerative medicine. As service to our authors readers, this journal provides supporting information supplied authors. Such materials are peer reviewed may be re-organized online delivery, but not copy-edited typeset. Technical support issues arising from (other than missing files) should addressed Please note: The publisher responsible content functionality of any Any queries content) directed corresponding author article.