One‐Shot Immunomodulatory Nanodiamond Agents for Cancer Immunotherapy

• DOI: 10.1002/adma.201506232
• Publication Date: 2016-02-02T09:27:29Z
• Authors: Yu Zhang; Zhifen Cui; Huating Kong; Kai Xia; Liang Pan; Jiang Li; Yanhong Sun; Jiye Shi; Lihua Wang; Ying Zhu; Chunhai Fan
• Keywords: Drug Carriers; Mice, Inbred ICR; Microscopy, Confocal; Transplantation, Heterologous; Oligonucleotides; Mice, Nude; 02 engineering and technology; Nanodiamonds; 3. Good health; Disease Models, Animal; Mice; RAW 264.7 Cells; Cell Line, Tumor; Neoplasms; Animals; Cytokines; Humans; Female; Immunotherapy; 0210 nano-technology

The use of functional nanodiamonds (fNDs) to deliver CpG oligonucleotides (ODNs) for sustained immunostimulation is reported. It is demonstrated that monotherapy using this immunostimulatory agent significantly suppresses the tumor growth in two murine tumor models. This fND-based nanoagent opens new opportunities for immunotherapy, as well as clinical applications of various types of therapeutic nucleic acids.