Cancer‐Cell‐Biomimetic Nanoparticles for Targeted Therapy of Homotypic Tumors

• DOI: 10.1002/adma.201602173
• Publication Date: 2016-09-15T06:19:10Z
• Authors: Huiping Sun; Jinghan Su; Qingshuo Meng; Qi Yin; Lingli Chen; Wangwen Gu; Pengcheng Zhang; Zhiwen Zhang; Haijun Yu; Siling Wang; Yaping Li
• Keywords: 01 natural sciences; 0104 chemical sciences; 3. Good health

A unique biomimetic drug-delivery system composed of 4T1-breast-cancer-cell membranes and paclitaxel-loaded polymeric nanoparticles (PPNs) (cell-membrane-coated PPNs), demonstrates superior interactions to its source tumor cells and elongated blood circulation, and displays highly cell-specific targeting of the homotypic primary tumor and metastases, with successful inhibition of the growth and lung metastasis of the breast cancer cells.