Fluorogenic 2D Peptidosheet Unravels CD47 as a Potential Biomarker for Profiling Hepatocellular Carcinoma and Cholangiocarcinoma Tissues

• DOI: 10.1002/adma.201604253
• Publication Date: 2016-11-21T12:56:42Z
• Authors: Yun‐Han Ma; Wei‐Tao Dou; Yu‐Fei Pan; Li‐Wei Dong; Ye‐Xiong Tan; Xiao‐Peng He; He Tian; Hong‐Yang Wang
• Keywords: Carcinoma, Hepatocellular; Liver Neoplasms; CD47 Antigen; 02 engineering and technology; 3. Good health; Cholangiocarcinoma; Bile Ducts, Intrahepatic; Bile Duct Neoplasms; Biomarkers, Tumor; Humans; Peptides; 0210 nano-technology

A 2D peptidosheet unravels CD47 as a potential biomarker to image hepatocarcinoma and cholangiocarcinoma cells and tissues. Supramolecular assembly between water-soluble 2D MoS2 and a peptide probe produces the 2D peptidosheet suited for the profiling of hepatocarcinoma and cholangiocarcinoma tissues over healthy tissues on clinical specimens.