Sequentially Responsive Shell‐Stacked Nanoparticles for Deep Penetration into Solid Tumors

• DOI: 10.1002/adma.201701170
• Publication Date: 2017-06-20T12:51:05Z
• Authors: Jinjin Chen; Jianxun Ding; Yucai Wang; Jianjun Cheng; Shengxiang Ji; Xiuli Zhuang; Xuesi Chen
• Keywords: Penetration (warfare); Surface charge

Nanomedicine to overcome both systemic and tumor tissue barriers ideally should have a transformable size surface, maintaining certain negative surface charge for prolonged circulation, while reducing smaller switching positive efficient penetration retention in the interstitial space throughout tissue. However, design of such dual-transformable nanomedicine is rarely reported. Here, shell-stacked nanoparticle (SNP) reported, which can undergo remarkable reduction from about 145 40 nm, reversal -7.4 8.2 mV at acidic tissue, enhanced uptake by cells deep The disulfide-cross-linked core maintains stability particle prevents undesired premature drug release until shedding shell, accelerates cleavage more exposed disulfide bond sand intracellular release. SNP penetrates 1 mm into xenografted A549 lung carcinoma, four times depth nontransformable one. doxorubicin (DOX)-loaded (SNP/DOX) shows significant antitumor efficacy nearly eradicates tumor, substantiating importance nanomedicine.