Paintable and Rapidly Bondable Conductive Hydrogels as Therapeutic Cardiac Patches

• DOI: 10.1002/adma.201704235
• Publication Date: 2018-04-24T07:51:08Z
• Authors: Shuang Liang; Yinyu Zhang; Hongbo Wang; Ziyang Xu; Jingrui Chen; Rui Bao; Baoyu Tan; Yuanlu Cui; Guanwei Fan; Wenxin Wang; Wei Wang; Wenguang Liu
• Keywords: Polypyrrole

Abstract In recent years, cardiac patches have been developed for the treatment of myocardial infarction. However, fixation approaches onto tissue through suture or phototriggered reaction inevitably cause new damage. Herein, a paintable hydrogel is constructed based on Fe 3+ ‐triggered simultaneous polymerization covalently linked pyrrole and dopamine in hyperbranched chains where situ formed conductive polypyrrole also uniquely serves to crosslink network. This adhesive can be conveniently painted as patch heart surface without adverse liquid leakage. The functional whose conductivity equivalent that normal myocardium strongly bonded beating within 4 weeks, accordingly efficiently boosting transmission electrophysiological signals. Eventually, reconstruction function revascularization infarct are remarkably improved. translatable suture‐free strategy reported this work promising address human clinical challenges engineering.