Tissue Mimicry in Morphology and Composition Promotes Hierarchical Matrix Remodeling of Invading Stem Cells in Osteochondral and Meniscus Scaffolds

• DOI: 10.1002/adma.201706754
• Publication Date: 2018-05-30T18:47:42Z
• Authors: Kai Stuckensen; Andrea Schwab; Markus Knauer; Emma Muiños‐López; Franziska Ehlicke; Jenny Reboredo; Froilán Granero‐M...; Uwe Gbureck; Felipe Prósper; Heike Walles; Jürgen Groll
• Keywords: 0301 basic medicine; 03 medical and health sciences; Chondrocytes; Tissue Engineering; Tissue Scaffolds; Stem Cells; Molecular Mimicry; Humans; Meniscus; Mesenchymal Stem Cells

AbstractAn integral approach toward in situ tissue engineering through scaffolds that mimic tissue with regard to both tissue architecture and biochemical composition is presented. Monolithic osteochondral and meniscus scaffolds are prepared with tissue analog layered biochemical composition and perpendicularly oriented continuous micropores by a newly developed cryostructuring technology. These scaffolds enable rapid cell ingrowth and induce zonal‐specific matrix synthesis of human multipotent mesenchymal stromal cells solely through their design without the need for supplementation of soluble factors such as growth factors.