Systemic Delivery of Monoclonal Antibodies to the Central Nervous System for Brain Tumor Therapy

• DOI: 10.1002/adma.201805697
• Publication Date: 2019-02-18T07:49:11Z
• Authors: Lei Han; Chaoyong Liu; Hongzhao Qi; Junhu Zhou; Jing Wen; Di Wu; Duo Xu; Meng Qin; Jie Ren; Qixue Wang; Lixia Long; Yang Liu; Irvin Chen; Xubo Yuan; Yunfeng Lu; Chunsheng Kang
• Keywords: Nanocapsules

As an essential component of immunotherapy, monoclonal antibodies (mAbs) have emerged as a class powerful therapeutics for treatment broad range diseases. For central nervous system (CNS) diseases, however, the efficacy remains limited due to their inability enter CNS. A platform technology is reported here that enables effective delivery mAbs CNS brain tumor therapy. This achieved by encapsulating within nanocapsules contain choline and acetylcholine analogues; such analogues facilitate penetration through brain-blood barrier sites. uncages therapeutic power various diseases remain poorly treated.