A Versatile Theranostic Nanoemulsion for Architecture‐Dependent Multimodal Imaging and Dually Augmented Photodynamic Therapy

• DOI: 10.1002/adma.201806444
• Publication Date: 2019-03-25T10:16:46Z
• Authors: Yifan Zhang; Shaowei Bo; Tao Feng; Xialing Qin; Yilin Wan; Shanshan Jiang; Chunxiao Li; Jing Lin; Tianfu Wang; Xin Zhou; Zhong‐Xing Jiang; Peng Huang
• Keywords: BODIPY; Nanocarriers

To design a clinically translatable nanomedicine for photodynamic theranostics, the ingredients should be carefully considered. A high content of nanocarriers may cause extra toxicity in metabolism, and multiple theranostic agents would complicate preparation process. These issues less concern if nanocarrier itself has most functions. In this work, poly(ethylene glycol)-boron dipyrromethene amphiphile (PEG-F54 -BODIPY) with 54 fluorine-19 (19 F) is synthesized employed to emulsify perfluorohexane (PFH) into nanoemulsion (PFH@PEG-F54 -BODIPY). The as-prepared PFH@PEG-F54 -BODIPY can perform architecture-dependent fluorescence/photoacoustic/19 F magnetic resonance multimodal imaging, providing more information about vivo structure evolution nanomedicine. Importantly, significantly enhances therapeutic effect BODIPY through both oxygen dissolving capability self-quenching molecules. More interestingly, shows level tumor accumulation long retention time, allowing repeated light irradiation after single-dose intravenous injection. "all-in-one" simple composition, remarkable efficacy, novel treatment pattern, thus presents an intriguing avenue developing agents.