Metabolizable Semiconducting Polymer Nanoparticles for Second Near‐Infrared Photoacoustic Imaging

• DOI: 10.1002/adma.201808166
• Publication Date: 2019-01-21T12:56:27Z
• Authors: Yuyan Jiang; Paul Kumar Upputuri; Chen Xie; Ziling Zeng; Arunima Sharma; Xu Zhen; Jingchao Li; Jiaguo Huang; Manojit Pramanik; Kanyi Pu
• Keywords: Biodegradable Materials; :Engineering::Chemical engineering [DRNTU]; 02 engineering and technology; Photoacoustic Imaging; 0210 nano-technology

Photoacoustic (PA) imaging in the second near-infrared (NIR-II) window (1000-1700 nm) holds great promise for deep-tissue diagnosis due to reduced light scattering and minimized tissue absorption; however, exploration of such a noninvasive technique is greatly constrained by lack biodegradable NIR-II absorbing agents. Herein, first series metabolizable PA agents are reported based on semiconducting polymer nanoparticles (SPNs). Such completely organic nanoagents consist π-conjugated yet oxidizable optical as generator hydrolyzable amphiphilic particle matrix provide water solubility. The obtained SPNs readily degraded myeloperoxidase lipase abundant phagocytes, transforming from nonfluorescent (30 into NIR fluorescent ultrasmall metabolites (≈1 nm). As such, these can be effectively cleared out via both hepatobiliary renal excretions after systematic administration, leaving no toxicity living mice. Particularly possess high photothermal conversion efficiencies emit bright signals at 1064 nm, enabling sensitive subcutaneous tumor deep brain vasculature through intact skull animals low dosage. This study thus provides generalized molecular design toward materials biophotonic applications window.