A Mesoporous Nanoenzyme Derived from Metal–Organic Frameworks with Endogenous Oxygen Generation to Alleviate Tumor Hypoxia for Significantly Enhanced Photodynamic Therapy

• DOI: 10.1002/adma.201901893
• Publication Date: 2019-05-16T11:40:59Z
• Authors: Dongdong Wang; Huihui Wu; Wei Qi Lim; Soo Zeng Fiona Phua; Pengping Xu; Qianwang Chen; Zhen Guo; Yanli Zhao
• Keywords: Mesoporous organosilica; Biocompatibility

Tumor hypoxia compromises the therapeutic efficiency of photodynamic therapy (PDT) as local oxygen concentration plays an important role in generation cytotoxic singlet (1 O2 ). Herein, a versatile mesoporous nanoenzyme (NE) derived from metal-organic frameworks (MOFs) is presented for situ endogenous to enhance PDT efficacy under bioimaging guidance. The NE constructed by first coating manganese-based MOFs with silica, followed facile annealing process ambient atmosphere. After removing silica shell and post-modifying polydopamine poly(ethylene glycol) improving biocompatibility, obtained loaded chlorin e6 (Ce6), commonly used photosensitizer PDT, high loading capacity. Upon through catalytic reaction between amount H2 , hypoxic tumor microenvironment relieved. Thus, Ce6-loaded serves -activated supplier increase significantly enhanced antitumor vitro vivo. In addition, also shows T2 -weighted magnetic resonance imaging ability its vivo tracking. This work presents interesting biomedical use MOF-derived multifunctional theranostic agent cancer therapy.