A Metal‐Organic Framework (MOF) Fenton Nanoagent‐Enabled Nanocatalytic Cancer Therapy in Synergy with Autophagy Inhibition

• DOI: 10.1002/adma.201907152
• Publication Date: 2020-02-13T16:42:25Z
• Authors: Bowen Yang; Li Ding; Heliang Yao; Yu Chen; Jianlin Shi
• Keywords: Cancer Therapy

Nanocatalytic medicine has been developed recently to trigger intratumoral generation of highly toxic reactive oxygen species (ROS) for cancer therapy, which, unfortunately, suffers from compromised therapeutic efficacy due a self-protective mechanism, autophagy, cells mitigate oxidative damage. In this work, during the efforts ROS by nanocatalytic medicine, pharmacological autophagy inhibition strategy is implemented augmenting ROS-induced damage synergetic therapy. An iron-containing metal-organic framework [MOF(Fe)] nanocatalyst as peroxidase mimic used catalyze oxidizing •OH radicals specifically within cells, while chloroquine applied deacidify lysosomes and inhibit cutting off self-protection pathway under severe stress. Cancer fail extract their components detoxicate strengthen themselves, finally succumbing Both in vitro vivo results demonstrate synergy between therapy inhibition, suggesting that such combined applicable amplify tumor-specific may be informative future design regimen.