Self‐Amplifying Nanotherapeutic Drugs Homing to Tumors in a Manner of Chain Reaction

• DOI: 10.1002/adma.202002094
• Publication Date: 2020-12-31T10:57:19Z
• Authors: Yue Wang; Na Shen; Ying Wang; Yu Zhang; Zhaohui Tang; Xuesi Chen
• Keywords: Conjugate

Abstract Active tumor‐targeting drug delivery has great potency in cancer therapy. However, the targeting efficiency of traditional active nanotherapeutic drugs is limited by scarcity their accessible targets/receptors tumors. Here, a novel self‐amplifying strategy with chain reaction mechanism developed. A coagulation peptide (GNQEQVSPLTLLKXC, termed A15)‐decorated poly(L‐glutamic acid)‐ graft ‐maleimide poly(ethylene glycol)/combretastatin A4 conjugate (A15‐PLG‐CA4) prepared to obtain platform homing After administration tumor‐bearing mice, A15‐PLG‐CA4 starts cycle consisting intratumoral hemorrhage, target FXIIIa amplification, blood clot binding, and CA4 release In this way, increases level its targets (FXIIIa) manner reaction. The activity at 8 h 4.1‐fold more than one 0 C26 tumors treated A15‐PLG‐CA4. total concentration 24 2.9‐fold control. shows significantly higher antitumor effect against large (≈500 mm 3 ) thanks remarkable ability compared Therefore, report highlights potential development next generation for tumor