Exploiting Unique Alignment of Cobalt Ferrite Nanoparticles, Mild Hyperthermia, and Controlled Intrinsic Cobalt Toxicity for Cancer Therapy

• DOI: 10.1002/adma.202003712
• Publication Date: 2020-10-01T17:52:35Z
• Authors: Preethi Bala Bala...; Niccolò Silvestri; Tamara Fernandez‐...; Federica Marinaro; Soraia Fernandes; Sergio Fiorito; Mario Miscuglio; David Serantes; Sergiu Ruta; Karen Livesey; Ondrej Hovorka; Roy Chantrell; Teresa Pellegrino
• Keywords: Hyperthermia therapy; Magnetic hyperthermia; Hyperthermia Treatment

Abstract Nanoparticle‐based magnetic hyperthermia is a well‐known thermal therapy platform studied to treat solid tumors, but its use for monotherapy limited due incomplete tumor eradication at temperature (45 °C). It often combined with chemotherapy obtaining more effective therapeutic outcome. Cubic‐shaped cobalt ferrite nanoparticles (Co–Fe NCs) serve as agents and cytotoxic agent the known ion toxicity, allowing achievement of both heat effects from single platform. In addition this advantage, Co–Fe NCs have unique ability form growing chains under an alternating field (AMF). This chain formation, along mild intrinsic leads complete regression improved overall survival in vivo murine xenograft model, all clinically approved AMF conditions. Numerical calculations identify anisotropy main NCs’ feature generate such formations. novel combination can improve hyperthermia, inaugurating investigation mechanical behaviors AMF, new avenue cancer therapy.