Plasmonic Alloys Reveal a Distinct Metabolic Phenotype of Early Gastric Cancer

• DOI: 10.1002/adma.202007978
• Publication Date: 2021-03-20T08:14:56Z
• Authors: Haiyang Su; Xinxing Li; Lin Huang; Jing Cao; Mengji Zhang; Vadanasundari Ved...; Wen Di; Zhiqian Hu; Kun Qian
• Keywords: Metabolic pathway

Abstract Gastric cancer (GC) is a multifactorial process, accompanied by alterations in metabolic pathways. Non‐invasive profiling facilitates GC diagnosis at early stage leading to an improved prognostic outcome. Herein, mesoporous PdPtAu alloys are designed characterize the profiles human blood. The elemental composition optimized with heterogeneous surface plasmonic resonance, offering preferred charge transfer for photoinduced desorption/ionization and enhanced photothermal conversion thermally driven desorption. structure of further tuned controlled mesopores, accommodating metabolites only, rather than large interfering compounds. Consequently, alloy yields direct fingerprints laser mass spectrometry seconds, consuming 500 nL native plasma. A distinct phenotype revealed sparse learning, resulting precise area under curve 0.942. It envisioned that will open up new era minimally invasive blood analysis improve surveillance patients clinical setting.