Upregulating Aggregation‐Induced‐Emission Nanoparticles with Blood–Tumor‐Barrier Permeability for Precise Photothermal Eradication of Brain Tumors and Induction of Local Immune Responses

• DOI: 10.1002/adma.202008802
• Publication Date: 2021-04-24T06:21:37Z
• Authors: Ming Zhang; Wentao Wang; Mohsen Mohammadniaei; Tao Zheng; Qicheng Zhang; Jon Ashley; Shunjie Liu; Yi Sun; Ben Zhong Tang
• Keywords: 0301 basic medicine; 03 medical and health sciences; Magnetic resonance; Immune response; Glioblastoma; Photothermal therapy; 3. Good health

Abstract Compared to other tumors, glioblastoma (GBM) is extremely difficult treat. Recently, photothermal therapy (PTT) has demonstrated advanced therapeutic efficacy; however, because of the relatively low tissue‐penetration efficiency laser light, its application in deep‐seated tumors remains challenging. Herein, bradykinin (BK) aggregation‐induced‐emission nanoparticles (BK@AIE NPs) are synthesized; these offer selective penetration through blood–tumor barrier (BTB) and strong absorbance near‐infrared region (NIR). The BK ligand can prompt BTB adenosine receptor activation, which enhances transportation accumulation inside as confirmed by T 1 ‐weighted magnetic resonance fluorescence imaging. BK@AIE NPs exhibit high conversion under 980 nm NIR irradiation, facilitating treatment tumors. Tumor progression be effectively inhibited extend survival span mice after spatiotemporal PTT. irradiation eradicate tumor tissues release tumor‐associated antigens. It observed that PTT GBM‐bearing activates natural killer cells, CD3 + CD8 M1 macrophages GBM area, increasing efficacy. This study demonstrates NIR‐assisted represent a promising strategy for improved systematic elimination GBMs activation local brain immune privilege.