Conferring Ti‐Based MOFs with Defects for Enhanced Sonodynamic Cancer Therapy

• DOI: 10.1002/adma.202100333
• Publication Date: 2021-04-01T07:56:46Z
• Authors: Shuang Liang; Xiao Xiao; Lixin Bai; Bin Liu; Meng Yuan; Ping'an Ma; Maolin Pang; Ziyong Cheng; Jun Lin
• Keywords: Sonodynamic therapy; Biocompatible material; Cancer Therapy

Abstract The development of highly efficient, multifunctional, and biocompatible sonosensitizer is still a priority for current sonodynamic therapy (SDT). Herein, defect‐rich Ti‐based metal–organic framework (MOF) (D‐MOF(Ti)) with greatly improved sonosensitizing effect simply constructed used enhanced SDT. Compared the commonly TiO 2 , D‐MOF(Ti) results in superior reactive oxygen species (ROS) yield under ultrasound (US) irradiation due to its narrow bandgap, which principally improves US‐triggered electron–hole separation. Meanwhile, existence Ti 3+ ions, also exhibits high level Fenton‐like activity enable chemodynamic therapy. Particularly, US as excitation source SDT can simultaneously enhance reaction achieve remarkably synergistic outcomes oncotherapy. More importantly, be degraded metabolized out body after completion therapeutic functions without off‐target toxicity. Overall, this work identifies novel Ti‐familial harboring great potential cancer