An Innovative Solvent‐Responsive Coiling–Expanding Stent

• DOI: 10.1002/adma.202101005
• Publication Date: 2021-07-05T06:40:20Z
• Authors: Shuo Shi; Miao Cui; Fengxin Sun; Kunkun Zhu; Mohammad Irfan Iqbal; Xiaoyu Chen; Bin Fei; Robert K. Y. Li; Qingyou Xia; Jinlian Hu
• Keywords: Biocompatibility; Vascular tissue; Ex vivo

Coronary artery disease is the "first killer" in world, while classical treatment for this to implant stent. An ideal vascular stent should be nontoxic with self-expanding characteristics, quick expanding speed, and appropriate mechanical supporting property. However, no existing covers all properties. Herein, a two-way shape-memory cellulose stent, which can realize shape adjustments by mild solutions such as water alcohol, constructed. The properties, cell toxicity, biocompatibility, are systemically investigated ex vivo experiment well molecule simulation theoretical modeling, revealing that achieved bilayer films (BSMFs) used an artificial In particular, made from BSMFs shows superb biocompatibility according live/dead viability assays. Ex experiments reveal novel support arteria coronaria sinistra, or left main coronary artery, at opening state cross-section of vessel becomes two times larger than initial after implantation. Thus, it believed effective scalable make meritorious fundamental contributions biomaterials science practical applications stents.