A Robust Narrow Bandgap Vanadium Tetrasulfide Sonosensitizer Optimized by Charge Separation Engineering for Enhanced Sonodynamic Cancer Therapy

• DOI: 10.1002/adma.202101467
• Publication Date: 2021-07-23T07:26:05Z
• Authors: Shuang Liang; Bin Liu; Xiao Xiao; Meng Yuan; Ling Yang; Ping'an Ma; Ziyong Cheng; Jun Lin
• Keywords: Sonodynamic therapy

The development and optimization of sonosensitizers for elevating intratumoral reactive oxygen species (ROS) are definitely appealing in current sonodynamic therapy (SDT). Given this, branched vanadium tetrasulfide (VS4 ) nanodendrites with a narrower bandgap (compared the most extensively explored sonosensitizers) presented as new source sonosensitizer, which allows more effortless separation sono-triggered electron-hole pairs ROS generation. Specifically, platinum (Pt) nanoparticles endogenous high levels glutathione (GSH) rationally engineered to further optimize its sono-sensitized performance. As cocatalyst, Pt is conducive trapping electrons, whereas GSH, natural hole-scavenger, tends capture holes. Compared pristine VS4 GSH-Pt-VS4 nanocomposite can greatly prolong lifetime charge confer highly efficacious production activity. Furthermore, such nanoplatforms capable reshaping tumor microenvironments realize overproduction, contributed by overcoming hypoxia improve SDT-triggered singlet production, catalyzing endogenic hydrogen peroxide into destructive hydroxyl radicals chemodynamic therapy, depleting GSH amplify oxidative stress. All these combined effects result significantly efficient suppression outcome. This study enriches sonosensitizer research proves that be optimized engineering strategy.