High‐Strength and Injectable Supramolecular Hydrogel Self‐Assembled by Monomeric Nucleoside for Tooth‐Extraction Wound Healing

• DOI: 10.1002/adma.202108300
• Publication Date: 2022-01-23T04:04:22Z
• Authors: Zheng Wang; Yanan Zhang; Yijia Yin; Jiang Liu; Peiran Li; Yuxi Zhao; Ding Bai; Hang Zhao; Xianglong Han; Qianming Chen
• Keywords: Biocompatibility; Gelatin; Distilled water

Hydrogels with high mechanical strength and injectability have attracted extensive attention in biomedical tissue engineering. However, endowing a hydrogel both properties is challenging because they are generally inversely related. In this work, by constructing multi-hydrogen-bonding system, high-strength injectable supramolecular successfully fabricated. It constructed the self-assembly of monomeric nucleoside molecular gelator (2-amino-2'-fluoro-2'-deoxyadenosine (2-FA)) distilled water/phosphate buffered saline as solvent. Its storage modulus reaches 1 MPa at concentration 5.0 wt%, which strongest comprising an ultralow-molecular-weight (MW < 300) gelator. Furthermore, it exhibits excellent shear-thinning injectability, completes sol-gel transition seconds after injection 37 °C. The system essentially based on synergistic interactions between double NH2 groups, water molecules, 2'-F atoms. 2-FA biocompatibility antibacterial activity. When applied to rat molar extraction sockets, compared natural healing commercial hemorrhage agent gelatin sponge, faster degradation induces less osteoclastic activity inflammatory infiltration, resulting more complete bone healing. summary, study provides ideas for proposing multifunctional, high-strength, various engineering applications.